A Novel Glucosamine-Based Cannabidiol Complex Based on Intermolecular Bonding with Improved Water Solubility
Abstract In this study, a new, patented form of a water-soluble cannabidiol (CBD) complex was synthesised and tested. The formation…
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1H, 13C, 15N backbone chemical shift assignment of P18ink4c from Danio rerio (zebrafish) using solution-state NMR spectroscopy
Abstract The INK4 family of proteins restricts uncontrolled cell cycle progression by inhibiting cyclin-dependent kinases 4 and 6. The family…
Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients
Abstract The tumor ecosystem heterogeneity of papillary thyroid carcinoma (PTC) is poorly characterized in children and young adult patients (CAYA‐PTC).…
The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction
Abstract Nicotine and cigarette/tobacco use continue to be a prevalent public health issue worldwide. The transition to nicotine addiction occurs…
Green solvent-based extraction of Cannabis sativa L. by-products: enhancing antioxidant potential and cannabinoid enrichment using MCT oil
Abstract Background: With the growing interest in the therapeutic applications of Cannabis sativa L., understanding how extraction techniques influence its…
Formulation and Functional Characterization of a Cannabidiol-Loaded Nanoemulsion in Canine Mammary Carcinoma Cells
Abstract Background/Objectives: Mammary carcinoma is a common disease in female dogs. Cannabidiol (CBD) can inhibit cell proliferation and induce apoptosis…
Synthesis, Molecular Docking, and Biological Studies of New Naphthalene‐1,4‐Dione‐Linked Phenylpiperazine and Thioether
Abstract Quinones are an important family of chemical compounds that are used in the development of anticancer drugs. Due to…
Evidence and reality: an observational study on pharmacological outcomes in advanced head and neck tumors
Abstract The Catalan Institute of Oncology (ICO) is a comprehensive centre for the prevention, diagnosis, and treatment of cancer. At…
Psychoactive substances: novel molecular insights and therapeutic potential for Alzheimer’s disease
Abstract Alzheimer’s disease (AD) is a major neurodegenerative disorder that causes severe cognitive decline and poses a significant burden on…
Cannabidiol polarizes human neutrophils toward a cancer-promoting phenotype
Abstract Introduction: Cannabidiol (CBD) is widely used as a natural alternative supplementary treatment for side effects and symptom relief in…