Cannabinoids, Medical Cannabis, and Colorectal Cancer Immunotherapy
Abstract Colorectal cancer is a major public health problem. Unfortunately, currently, no effective curative option exists for this type of…
Free
Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels
Abstract Systems pharmacology employs computational and mathematical methods to study the network of interactions a drug may have within complex…
Hepatic Cannabinoid Signaling in the Regulation of Alcohol-Associated Liver Disease
Abstract PURPOSE: The endocannabinoid system has emerged as a key regulatory signaling pathway in the pathophysiology of alcohol-associated liver disease…
Synthesis, characterization and stress-testing of a robust quillaja saponin stabilized oil-in-water phytocannabinoid nanoemulsion
Abstract Background: This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization. \(\text…
Effect of Varying Levels of Hempseed Meal Supplementation on Humoral and Cell-Mediated Immune Responses of Goats
Abstract Simple Summary: Hempseed meal (HSM) is a byproduct of hemp oil production and is high in protein, fiber, and…
Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences
Abstract Thromboangiitis obliterans (TAO) or Buerger’s disease is a segmental inflammatory, thrombotic occlusive peripheral vascular disease with unknown aetiology that…
Cellular distribution of cannabinoid‐related receptors TRPV1, PPAR‐gamma, GPR55 and GPR3 in the equine cervical dorsal root ganglia
Abstract Background: The activation of cannabinoid and cannabinoid‐related receptors by endogenous, plant‐derived or synthetic cannabinoids may exert beneficial effects on…
CBD Alleviates Liver Injuries in Alcoholics With High-Fat High-Cholesterol Diet Through Regulating NLRP3 Inflammasome–Pyroptosis Pathway
Abstract Alcohol abuse and high-fat diet–induced liver diseases have been the most prevalent chronic liver diseases and the leading reasons…
In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation
Abstract Background: Cannabis has been used worldwide for centuries for industrial, recreational and medicinal use, however, to date no successful…
Identification of BiP as a CB1 Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain
Abstract Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1…