Targeting the Endocannabinoidome in Pancreatic Cancer
Abstract Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer…
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Cannabidiol Downregulates Myocardial de Novo Ceramide Synthesis Pathway in a Rat Model of High-Fat Diet-Induced Obesity
Abstract It is known that metabolic disturbances, including obesity, predispose to an increased incidence of cardiovascular diseases. Elevated consumption of…
Marijuana Is Associated With a Hormonal Imbalance Among Several Habits Related to Male Infertility: A Retrospective Study
Abstract Marijuana is one of the most consumed drugs worldwide. There is increasing evidence of an association between marijuana and…
The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors
Abstract The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased…
Analysis of the Aerosol Generated from Tetrahydrocannabinol, Vitamin E Acetate, and Their Mixtures
Abstract E-cigarette, or vaping, product use–associated lung injury (EVALI) outbreak was linked to vitamin E acetate (VEA) used as a…
Cannabidiol and Terpene Formulation Reducing SARS-CoV-2 Infectivity Tackling a Therapeutic Strategy
Abstract Conclusions and Impact: We demonstrate the virucide effectiveness of CBD and terpene-based formulations. F2TC reduces the infectivity by 17%,…
Chronic Administration of Cannabinoid Receptor 2 Agonist (JWH-133) Increases Ectopic Ovarian Tumor Growth and Endocannabinoids (Anandamide and 2-Arachidonoyl Glycerol) Levels in Immunocompromised SCID Female Mice
Abstract Cannabinoid-based therapies are increasingly being used by cancer patients to treat chemotherapy-induced nausea and vomiting. Recently, cannabinoids have gained…
Functional brain connectomes reflect acute and chronic cannabis use
Abstract Resting state fMRI has been employed to identify alterations in functional connectivity within or between brain regions following acute…
Assessment of the Influence of Selected Technological Parameters on the Morphology Parameters of the Cutting Surfaces of the Hardox 500 Material Cut by Abrasive Water Jet Technology
Abstract This article deals with the evaluation of selected aspects of abrasive water jet technology (AWJ) in the cutting of…
Cannabis sativa Extract Induces Apoptosis in Human Pancreatic 3D Cancer Models: Importance of Major Antioxidant Molecules Present Therein
Abstract In recent years, interest in Cannabis sativa L. has been rising, as legislation is moving in the right direction.…