Cannabidiol and epilepsy in Brazil: a current review
Abstract Background: Cannabidiol (CBD) has become a promising therapeutic option in the treatment of epilepsy. Recent studies provide robust evidence…
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The Cannabis-Induced Epigenetic Regulation of Genes Associated with Major Depressive Disorder
Abstract The prevalence of depression is increasing worldwide, as is the number of people suffering from treatment-resistant depression; these patients…
The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics
Abstract Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative…
Antibacterial, Antibiofilm, and Antioxidant Activity of 15 Different Plant-Based Natural Compounds in Comparison with Ciprofloxacin and Gentamicin
Abstract Plant-based natural compounds (PBCs) are comparatively explored in this study to identify the most effective and safe antibacterial agent/s…
Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain circuits
Abstract Although the cannabinoid type-2 receptor (CB2) is highly expressed in the immune system, emerging evidence points to CB2 playing…
The epiphany derived from T-cell–inflamed profiles: Pan-cancer characterization of CD8A as a biomarker spanning clinical relevance, cancer prognosis, immunosuppressive environment, and treatment responses
Abstract CD8A encodes the CD8 alpha chain of αβT cells, which has been proposed as a quantifiable indicator for the…
Case Report Highlighting Cardiovascular Effects of Concomitant Use of Methamphetamine and Marijuana
Abstract We present the case of a 51-year-old male admitted for cardiovascular complications in the face of concomitant chronic methamphetamine…
Acute Kidney Injury (AKI) in Young Synthetic Cannabinoids Abusers
Abstract Background. Synthetic cannabinoid-related acute kidney injury represents an increasingly important public health issue due to the diagnostic challenges given…
Cannabidivarin alleviates neuroinflammation by targeting TLR4 co-receptor MD2 and improves morphine-mediated analgesia
Abstract Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that regulates the activation of immune cells, which is a…
Can cannabis kill? Characteristics of deaths following cannabis use in England (1998–2020)
Abstract Background: Cannabis is the most widely used illegal drug but is rarely considered a causal factor in death. Aims:…