The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism
Abstract The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium and enteroendocrine cells, and is…
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Cannabidiol Enhances Microglial Beta-Amyloid Peptide Phagocytosis and Clearance via Vanilloid Family Type 2 Channel Activation
Abstract Alzheimer’s disease (AD) is associated with the accumulation and aggregation of amyloid in the brain. The cation channel TRPV2…
Impact of Δ9-Tetrahydrocannabinol on Rheumatoid Arthritis Synovial Fibroblasts Alone and in Co-Culture with Peripheral Blood Mononuclear Cells
Abstract δ9-Tetrahydrocannabinol (THC) has demonstrated anti-inflammatory effects in animal models of arthritis, but its mechanism of action and cellular targets…
Distinct Effects of Cannabidiol on Sphingolipid Metabolism in Subcutaneous and Visceral Adipose Tissues Derived from High-Fat-Diet-Fed Male Wistar Rats
Abstract Available data suggest that cannabidiol (CBD) may ameliorate symptoms of insulin resistance by modulating the sphingolipid concentrations in particular…
Medicinal Cannabis Prescribing in Australia: An Analysis of Trends Over the First Five Years
Abstract A regulatory framework allowing legal access to medicinal cannabis (MC) products has operated in Australia since November 2016. MC…
Gender Differences in Medication Adverse Effects Experienced by People Living With Chronic Pain
Abstract Objectives: Understanding gender differences in chronic pain (CP) outcome research is essential to optimal treatment delivery. This study explored…
Maternal Smoking, Alcohol and Recreational Drug Use and the Risk of SIDS Among a US Urban Black Population
Abstract Background: Rates of sudden infant death syndrome (SIDS) are twice as high among Black infants compared to white infants…
Acute Cannabigerol Administration Lowers Blood Pressure in Mice
Abstract Cannabigerol is a cannabinoid compound synthesized by Cannabis sativa, which in its acid form acts as the substrate for…
Medical Cannabis Activity Against Inflammation: Active Compounds and Modes of Action
Abstract Inflammation often develops from acute, chronic, or auto-inflammatory disorders that can lead to compromised organ function. Cannabis (Cannabis sativa)…
Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
Abstract Background: Human pentameric ligand-gated ion channels (pLGICs) comprise nicotinic acetylcholine receptors (nAChRs), 5-hydroxytryptamine type 3 receptors (5-HT3Rs), zinc-activated channels…