Prevalence of Substance Use in Northwest Syria: A Cross-Sectional Study
Abstract Objectives: Syria has undergone significant socio-political turmoil since 2011 as internal conflict displaced portions of the population, destroyed infrastructure,…
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Natural Compounds Derived from Chilean Species and Their Cytotoxic Potential Against Cancer
Abstract Medicinal plants have been used in therapy since ancient times and remain important in human health. Traditionally, they have…
Cannabis Intoxication Does Not Impact Nutritional Status in Patients With Small Burns
Abstract Patients with burn injuries exhibit one of the most intense hypermetabolic responses among critically ill populations, making them highly…
Development and Characterization of Dissolving Microneedles for the Buccal Delivery of Cannabidiol (CBD)
Abstract This study aimed to develop dissolving microneedles (MNs) for the buccal delivery of cannabidiol (CBD). CBD is a non-psychotomimetic…
Cannabidiol in Neurology: Current Insights and Translational Perspectives
Abstract Cannabidiol (CBD) is one of the most studied compounds of Cannabis sativa and has attracted significant interest due to…
Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles
Abstract Background: Methamphetamine (MA) use in people living with HIV (PLWH) has been linked to neurocognitive and behavioral dysregulation. We…
Pharmacogenetic association study of cannabis use in chronic pain
Abstract Background: Pain is one of the leading causes of disability worldwide. Despite the various pharmacological treatments available, patients with…
Isolation and Functional Characterization of Carob-Derived Nanovesicles Reveals Anti-Inflammatory and Regenerative Potential
Abstract Plant-derived nanovesicles (PDNVs) are increasingly recognized as mediators of intercellular communication in plants, where they play roles in defense,…
Investigating the psychedelic hypothesis of kykeon, the sacred elixir of the Eleusinian Mysteries
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-39568-3. Article type: Research Article Keywords: Psychedelic, Eleusinian Mysteries,…
Integrated Computational Investigation of Cannabis sativa Phytoconstituents as Putative Multi-Target Inhibitors in Skin Cancer: A Molecular Docking, Dynamics, and ADMET Profiling Study
Abstract Background: Skin cancer progression is driven by the dysregulation of key oncogenic signaling pathways, including EGFR, BRAF V600E, and…