Cannabidiol in Food and Food Supplements: Drug, Novel Food and Hazard Triangle
Abstract The concept of the “cannabidiol (CBD) Hazard Triangle” reflects the unique position of CBD at the intersection of three…
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Influence of cannabis potency on mental health outcomes among adolescents and young adults: scoping review
Abstract Background: Recently, there has been a significant rise in potency (% tetrahydrocannabinol (THC)) of cannabis products globally. As such,…
Endocannabinoid system modulation in bruxism: a neurobiological hypothesis and translational model of ECS-targeted intervention
Abstract Bruxism is a multifactorial motor behavior of predominantly central origin, characterized by repetitive masticatory muscle activity and associated with…
Advances in drug addiction research using Caenorhabditis elegans: behavioral and molecular mechanisms
Abstract Drug addiction is a complex, chronic, and relapsing neurological disorder characterized by persistent neuroadaptation and a substantial public health…
The relevance of cannabinoid receptor 2 in the central nervous system: an update over the last 3 years
Abstract The endocannabinoid system is a neuromodulatory network regulating synaptic plasticity, neuronal activity, and neuroinflammatory responses in both the central…
Medicinal Plants and Their Bioactive Phytochemicals as Emerging Therapeutic Strategies for Alzheimer’s Disease: An Integrative Review of Preclinical and Clinical Evidence
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by β-amyloid deposition, tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, neuroinflammation,…
Breast milk Δ9-tetrahydrocannabinol in cannabis users during the postpartum period: correlation between breast milk, maternal urine and saliva samples during early lactation
Abstract Introduction: Cannabis use during pregnancy and the postpartum period has increased in recent years, raising clinical concerns regarding maternal…
Systematic pan-cancer analysis reveals context-dependent prognostic and immunological roles of WDR1 with divergent effects in renal and gastric cancers
Abstract Background: WD-repeat domain 1 (WDR1), a key regulator of actin cytoskeleton dynamics, has been implicated in tumor progression. However,…
Suspected Cannabinoid Hyperemesis Syndrome in a Traveler from a Cannabis-Legal Country: A Case Report from Japan
Abstract Cannabinoid hyperemesis syndrome (CHS) is characterized by recurrent nausea, vomiting, and abdominal pain in chronic cannabis users. We report…
Antidepressant-like effects of cannabidiol when combined with temozolomide in adult rats
Abstract There is a need for characterizing more efficacious therapeutic strategies for glioblastoma multiforme to overcome treatment resistance to the…