Microglia NLRP3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders
Abstract During the last decade, substance use disorders (SUDs) have been increasingly recognized as neuroinflammation-related brain diseases. Various types of…
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The endogenous cannabinoid system modulates male sexual behavior expression
Abstract The endocannabinoid system (ECS) plays a key neuromodulatory role in the brain. Main features of endocannabinoids (eCBs) are that…
The Role of the Endocannabinoid System in Binge Eating Disorder
Abstract Eating disorders are multifactorial disorders that involve maladaptive feeding behaviors. Binge eating disorder (BED), the most prevalent of these…
Shift handover quality in Saudi critical care units: determinants from nurses’ perspectives
Abstract Background: Nurses’ effective handover communication is vital for patient safety and quality of care. Few studies have empirically tested…
The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer’s Disease in AppNL-G-F Knock-In Mice
Abstract Simple Summary: Alzheimer’s disease (AD) is a complex, multifactorial disease where numerous components, such as environment, lifestyle, comorbidities, and…
Genome-wide DNA methylation association study of recent and cumulative marijuana use in middle aged adults
Abstract Marijuana is a widely used psychoactive substance in the US and medical and recreational legalization has risen over the…
Δ8-THC Induces Up-Regulation of Glutamatergic Pathway Genes in Differentiated SH-SY5Y: A Transcriptomic Study
Abstract Cannabinoids, natural or synthetic, have antidepressant, anxiolytic, anticonvulsant, and anti-psychotic properties. Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) are the most…
A Clinical Framework for Evaluating Cannabis Product Quality and Safety
Abstract Increase in medical cannabis use, along with available products, warrants the need for clinicians to be knowledgeable in evaluating…
The Cannabis sativa genetics and therapeutics relationship network: automatically associating cannabis-related genes to therapeutic properties through chemicals from cannabis literature
Abstract Background: Understanding the genome of Cannabis sativa holds significant scientific value due to the multi-faceted therapeutic nature of the…
Vapor Pressure, Vaping, and Corrections to Misconceptions Related to Medical Cannabis’ Active Pharmaceutical Ingredients’ Physical Properties and Compositions
Abstract Medical cannabis products contain dozens of active pharmaceutical ingredients (APIs) derived from the cannabis plant. However, their actual compositions…