FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites
Abstract FoxP3, the master regulator of Tregs, employs two DNA-binding modes to recognize diverse DNA sequences. It multimerizes on long…
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Identification of prognostic and cellular senescence gene E2F1 of papillary thyroid carcinoma through bioinformatics analyses and experimental verification
Abstract Objective: This work aimed to find a new prognostic cell senescence gene to predict the prognosis of patients with…
Impact of Pancreatic Stump Wrapping with Mesh on Post-Operative Pancreatic Fistula in Patients Undergoing Distal/Left Pancreatectomy for Malignant or Benign Diseases: A Systematic Review and Meta-Analysis
Abstract Background and Objectives: Post-Operative Pancreatic Fistula (POPF) is reported among 13% to 64% of cases following a distal/left pancreatectomy…
“Those pot heads” – perceived external stigma and self-stigma among cannabis users in Germany: prevalence and associations with socio-demographics, cannabis use patterns and psychological distress
Abstract Background: Cannabis users have been stigmatized in the course of the long-standing prohibition. A recent law change in Germany…
Social cognition in young adults who endorse a cannabis use disorder
Abstract Rationale: Cannabis use disorder (CUD) affects over 50 million people globally. Emerging evidence shows that some people with CUD…
Panoramic analysis of the biological function and clinical value of SLC38A2 in human cancers: a study based on pan-cancer and single-cell analysis
Abstract Background: Glutamine metabolic reprogramming is a hallmark of tumor progression and is highly correlated with poor clinical outcomes. The…
Young Smokers’ Therapy Preferences: App-Based vs. Face-to-Face Treatment in the Context of Co-Addictions
Abstract Background: Tobacco use remains a major public health concern among young adults and is often complicated by co-occurring addictive…
The AhR Is a Critical Regulator of the Pulmonary Response to Cannabis Smoke
Abstract Cannabis use is prevalent worldwide, with smoking being the most common method of consumption. When smoking cannabis, users are…
Nanotechnology for the Efficacious Delivery of Medicinal Cannabis and Pharmaceutical Medicines
Abstract The application of nanoparticles as nanomedicines, particularly for the targeted and efficacious delivery of drugs is an expanding platform…
Dual Roles of Signal Transducer and Activator of Transcription 1 (STAT1) in Cancer: Expression Patterns, Prognostic Significance, and Immune Associations Across Multiple Tumor Types
Abstract Background: Signal transducer and activator of transcription 1 (STAT1) is a pivotal transcription factor that plays a dual role…