Envisaging challenges for the emerging medicinal Cannabis sector in Lesotho
Abstract Background: Cultivation of Cannabis and its use for medical purposes has existed for millennia on the African continent. The…
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Cannabinoid and Orexigenic Systems Interplay as a New Focus of Research in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) remains a significant health challenge, with an increasing prevalence globally. Recent research has aimed to deepen…
Evaluation of Alternative Sources of Proteins and Other Nutrients with Potential Applications in Fish Nutrition
Abstract The European Union’s (EU) agricultural self-sufficiency is challenged by its reliance on imported plant proteins, particularly soy from the…
Sustainable cannabinoids purification through twin-column recycling chromatography and green solvents
Abstract Abstract: In the present study, twin-column recycling chromatography has been employed for the purification of a Cannabis extract by…
Cannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells
Abstract Cannabidivarin (CBDV) and cannabigerol (CBG) are minor phytocannabinoids from Cannabis sativa, whose health benefits have been reported. However, studies…
Using In Silico Molecular Docking to Explain Differences in Receptor Binding Behavior of HHC and THCV Isomers: Revealing New Binding Modes
Abstract Even slight structural differences between phytocannabinoid isomers are usually enough to cause a change in their biological properties. In…
Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region
Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from…
Comprehensive Assessment of the Effect of Multi-Cropping on Agroecosystems
Abstract Multi-cropping is becoming an increasingly popular technique in agriculture to tackle major and complex agroecosystem problems such as biodiversity…
Interplay between endocannabinoids and dopamine in the basal ganglia: implications for pain in Parkinson’s disease
Abstract Pain is a complex phenomenon, and basal ganglia circuitry integrates many aspects of pain including motor, emotional, autonomic, and…
Redox balance and immunity of piglets pre- and post-E. coli challenge after treatment with hemp or fish oil, and vitamin E
Abstract This study investigated the influence of polyunsaturated fatty acid composition and vitamin E supplementation on oxidative status and immune…