Substance Use among School-Going Adolescents and Young Adults in Rural Mpumalanga Province, South Africa
Abstract The ongoing public health crisis of substance use among school adolescents and young adults (AYAs) in South Africa is…
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Harm reduction strategies for cannabis-related problems: a literature review and typology
Abstract Measures that seek to minimise the health and social consequences of substance use are an integral part of national…
Activation of Piezo1 or TRPV2 channels inhibits human ureteral contractions via NO release from the mucosa
Abstract We aimed to investigate the expression and motor modulatory roles of several mechano-sensitive channels (MSCs) in human ureter. Human…
Impact of Cannabidiol and Exercise on Clinical Outcomes and Gut Microbiota for Chemotherapy-Induced Peripheral Neuropathy in Cancer Survivors: A Case Report
Abstract Chemotherapy-induced peripheral neuropathy (CIPN) remains a clinical challenge for up to 80% of breast cancer survivors. In an open-label…
Orexin receptor 2 agonist activates diaphragm and genioglossus muscle through stimulating inspiratory neurons in the pre-Bötzinger complex, and phrenic and hypoglossal motoneurons in rodents
Abstract Orexin-mediated stimulation of orexin receptors 1/2 (OX[1/2]R) may stimulate the diaphragm and genioglossus muscle via activation of inspiratory neurons…
The Reddit cannabis subjective highness rating scale: Applying computational social science to explore psychological and environmental correlates of naturalistic cannabis use
Abstract Social media data provide unprecedented access to discussions of active, naturalistic, and often real-time cannabis use in an era…
A feasibility study to assess the recruitment and retention of pregnant patients who regularly use cannabis
Abstract Objective: To assess first-trimester recruitment and retention of pregnant patients who regularly used cannabis, but not other substances, measured…
Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
Abstract The cannabinoid receptor type 1 (CB1R) is a promising therapeutic target for various neurodegenerative diseases, including HIV-1-associated neurocognitive disorder…
The potential of cannabinoids in managing cancer-related anorexia in older adults: a systematic review of the literature
Abstract Anorexia of Aging (AoA) is a highly prevalent syndrome among older adults. AoA links to adverse outcomes, such as…
Einschränkungen der Mobilität von älteren Verkehrsteilnehmern durch Medikamente, Alkohol und Cannabis
Abstract Viele Grunderkrankungen gehen mit Symptomen einher, die die Fähigkeit, komplexe Aufgaben des Alltags zu lösen, beeinträchtigen können. Hierzu gehört…