Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia
Abstract Converging findings have established that the endocannabinoid (eCB) system serves as a possible target for the development of new…
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Reelin Deficiency and Synaptic Impairment in the Adolescent Prefrontal Cortex Following Initial Synthetic Cannabinoid Exposure
Abstract Background: Adolescent cannabinoid exposure can have long-lasting effects on the brain, particularly in the prefrontal cortex, where the reelin…
Current and Potential Use of Biologically Active Compounds Derived from Cannabis sativa L. in the Treatment of Selected Diseases
Abstract Cannabis sativa L. contains numerous compounds with antioxidant and anti-inflammatory properties, including the flavonoids and the cannabinoids, particularly Δ-9-tetrahydrocannabinol…
Analyzing and predicting short-term substance use behaviors of persons who use drugs in the great plains of the U.S.
Abstract Background: Substance use induces large economic and societal costs in the U.S. Understanding the change in substance use behaviors…
Adverse events caused by cannabinoids in middle aged and older adults for all indications: a meta-analysis of incidence rate difference
Abstract Background: Cannabinoid-based medicines (CBMs) are being used widely in older people. However, information on the incidence of adverse events…
Pharmacokinetics of Oral Cannabinoid Δ8-Tetrahydrocannabivarin and Its Main Metabolites in Healthy Participants
Abstract Background: Tetrahydrocannabivarin (THCV) is a phytocannabinoid commonly found in cannabis with potential pharmacological properties; however, its post-acute pharmacokinetics (PK)…
Palmitoylethanolamide causes dose-dependent changes in brain function and the lipidome
Abstract The present studies were undertaken to understand the effects of the commonly used nutraceutical PEA on brain function and…
Avatar Intervention in Virtual Reality for Cannabis Use Disorder in Individuals With Severe Mental Disorders: Results From a 1-Year, Single-Arm Clinical Trial
Abstract Background: The dual diagnosis of cannabis use disorder (CUD) and severe mental disorder (SMD) results in clinically complex individuals.…
Cannabinoid-Induced Immunogenic Cell Death of Colorectal Cancer Cells Through De Novo Synthesis of Ceramide Is Partially Mediated by CB2 Receptor
Abstract Mounting evidence demonstrates that cannabinoids have anti-cancer properties. The mechanism by which the cannabinoids induce cell death is still…
Cytotoxicity of natural and synthetic cannabinoids and their synergistic antiproliferative effects with cisplatin in human ovarian cancer cells
Abstract Introduction: Cannabinoids are reported to suppress the growth of ovarian cancer cells, but it is unclear whether structural modifications…