System Analysis Identifies MYBL2 As a Novel Oncogene Target for Metastatic Prostate Cancer
Abstract Bone metastasis significantly contributes to the unfavorable prognosis observed in patients with prostate cancer. MYB proto-oncogene like 2 (MYBL2)…
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Cannabinoid spoilage, metabolism and cannabidiol(CBD) conversion to Tetrahydrocannabinol(THC) mechanisms with energetic parameters
Abstract Chemical redox mechanisms and thermodynamic parameters of the Cannabinoids Δ9-Tetrahydrocannabinol (THC) and cannabidiol (CBD) were determined theoretically and using…
Explore the possible influence of Sjogren’s syndrome on thyroid cancer: A literature data mining and meta-analysis
Abstract Objectives: To explore the potential influence of Sjogren’s syndrome (SS) on thyroid cancer (TC). Methods: First, a literature data…
LCAT in Cancer Biology: Embracing Epigenetic Regulation, Immune Interactions, and Therapeutic Implications
Abstract Lecithin cholesterol acyltransferase (LCAT) is a crucial enzyme in high-density lipoprotein (HDL) metabolism that is often dysregulated in cancers,…
Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
Abstract Introduction: Metastasis is the major cause of thyroid cancer morbidity and mortality. However, the mechanisms are still poorly understood.…
The Relationship of Socioeconomic Factors and Substance Abuse Treatment Dropout
Abstract Background: Treatment dropout in substance use disorder (SUD) programs poses a significant challenge to achieving successful outcomes and leads…
Medicinal Cannabis and Consumer Vulnerability in Australia: A Nexus of Policy and Market Factors
Abstract Introduction: Following the 2016 legalization of medicinal cannabis (MC) in Australia, significant barriers have led patients to seek unregulated…
Value signals guiding choices for cannabis versus non-drug rewards in people who use cannabis near-daily
Abstract Rationale: Despite the critical role of choice processes in substance use disorders, the neurobehavioral mechanisms guiding human decisions about…
Harnessing Hemp (Cannabis sativa L.) Seed Cake Proteins: From Concentrate Production to Enhanced Choux Pastry Quality
Abstract This study explores the production and valorization of hemp seed cake protein concentrate (HPC) as a functional ingredient to…
Nurses retention: the impact of transformational leadership, career growth, work well-being, and work-life Balance
Abstract Background: Nurse retention is critical for healthcare systems worldwide, as high turnover rates adversely affect patient care and organizational…