Illicit stimulants and ventricular arrhythmias: a longitudinal cohort study
Abstract Background and Aims: Ventricular tachycardia and ventricular fibrillation underlie many sudden cardiac deaths, but common lifestyle factors that predict…
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Multifaceted investigations of PSMB8 provides insights into prognostic prediction and immunological target in thyroid carcinoma
Abstract The Proteasome 20S subunit beta 8 (PSMB8) is an integral element of the immunoproteasome complex, playing a pivotal role…
Patterns of Polydrug Use in Patients Presenting at the Emergency Department with Acute Intoxication
Abstract Studies analyzing the prevalence of associated substance use are limited. Currently, the World Health Organization (WHO) defines polydrug use…
COMT Genetic Variants and BDNF Level Associations with Cannabinoid Plasma Exposure: A Preliminary Study
Abstract Cannabis sativa L. shows potent anti-inflammatory activity, resulting in an interesting pharmacological option for pain management. The aim of…
Genotoxic assessment of a Cannabis sativa L. extract
Abstract Context: As a naturally occurring terpenoid found in Cannabis sativa L. (Cannabaceae), cannabidiol (CBD) has gained public and industry…
New Terpenoids from Viguiera dentata: In Silico Pesticide‐Likeness Properties, Acetylcholinesterase Inhibition, Molecular Docking, and Evaluation against Spodoptera frugiperda
Abstract The chemical analysis of the melliferous plant Viguiera dentata (Asteraceae) yielded cycloartanes 1–9 (including the new compounds 7–9), ent‐kaurenes…
Thymidine Phosphorylase Inhibitory Potential and Molecular Docking Studies of Secondary Metabolites Isolated From Fernandoa adenophylla (Wall. ex G. Don) Steenis
Abstract This study investigates the potential of Fernandoa adenophylla, a South American plant, as a reservoir of compounds with thymidine…
Pan-Cancer Analysis Identifies a Ras-Related GTPase as a Potential Modulator of Cancer
Abstract Ras signaling regulates many cellular processes in cancer development. While well-known Ras-related oncogenes, such as KRAS, have been extensively…
Tumor tissue-of-origin classification using miRNA-mRNA-lncRNA interaction networks and machine learning methods
Abstract Introduction: MicroRNAs (miRNAs) regulate gene expression and play an important role in carcinogenesis through complex interactions with messenger RNAs…
Pericyte‐Assisted Vascular Lumen Organization in a Novel Dynamic Human Blood‐Brain Barrier‐on‐Chip Model
Abstract Organ‐on‐Chip (OoC) technology provides a powerful platform for neurovascular research, enabling the precise replication of the blood‐brain barrier (BBB)…