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Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
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Readable research linked to original sources
Browse normalized, publication-ready research with direct links to its evidence and source.
78 articles
Newest firstPain is prevalent among people with HIV (PWH), and many PWH who experience pain also use substances (illicit drug and/or unhealthy alcohol use). While cocaine use and cocaine and alcohol co-use are prevalent in this population, their effects on pain in PWH are unknown. This study aims to investigate the association of cocaine use and co-use of cocaine and alcohol with pain interference among PWH. We completed a se…
Open article record in new tab ↗Background Educational attainment (EA), which comprises cognitive (CogEA) and noncognitive (NonCogEA) components, is positively genetically correlated with alcohol and cannabis use but negatively correlated with alcohol and cannabis use disorders (AUD and CUD). These paradoxical associations suggest that shared genetic influences with EA may differ by level of substance involvement. Methods To test this, we examin…
Rationale Harmful alcohol use remains a significant global public health challenge. Examining variability in the acute subjective effects of alcohol and related neurobiological mechanisms may advance the understanding of susceptibility to harmful alcohol use. Research suggests the endocannabinoid (eCB) system may play an important role in mediating the reinforcing effects of alcohol. This study examined the relati…
Open article record in new tab ↗Background Romantic relationships are important contexts for substance use and emotional well-being. We tested the hypotheses that (i) genetic predispositions for alcohol consumption would be positively associated with partner substance use, (ii) partner substance use would moderate genetic influences on one's own alcohol outcomes, and (iii) partner discordance in substance use would be associated with lower emoti…
Rationale Widespread legalization of cannabis in the US in recent years has coincided with increasing use of alcohol and cannabis at the same time. Cannabis is thought to confer synergistic effects on alcohol intoxication, and the potential for increased cognitive impairment is a concern. Most prior co-administration studies have relied on low-THC cannabis, limiting generalizability to real-world consumption of hi…
Open article record in new tab ↗Background Medical cannabis is now commonly prescribed for a range of chronic health conditions. Many medical cannabis products contain delta-9-tetrahydrocannabinol (THC), the intoxicating component in cannabis, though it is unclear whether these products produce impairment when used as prescribed and at therapeutic doses. With current Australian laws prohibiting driving with any amount of THC in one's system, thi…
Open article record in new tab ↗Aim To examine the extent of polysubstance use in the general population of Croatia, determine trends in polysubstance use between 2011 and 2023, and identify distinct subgroups based on the patterns of polysubstance use and compare these subgroups across survey years. Methods Four studies were conducted between 2011 and 2023 on nationally representative samples of Croatian residents aged 15 to 64, with a total of…
Open article record in new tab ↗Background Cannabis has shown mixed results in its association with alcohol urge, which may be explained by individual differences. One such factor, working memory capacity (WMC) is associated with drug-related cue reactivity and implicated in alcohol use and problems. In the current study, we examined whether WMC moderates the acute effect of cannabis on alcohol urge in a randomized placebo-controlled crossover t…
Open article record in new tab ↗Background More severe substance use, defined as higher scores on validated measures of problematic use, is increasing within young adult populations. Substance use has been associated with mild traumatic brain injury (mTBI) and elevated symptoms of depression and anxiety. We aimed to understand the relationship between these factors and sex differences in a university sample. Method 894 university students (372 m…
Open article record in new tab ↗Background and objectives Adolescent substance use is a critical public health concern with significant long-term consequences, yet research on disparities by sexual orientation remains limited. Despite the unique stressors faced by sexual minority youth-particularly bisexual individuals-that increase their risk for substance use, most studies investigate disparities among older adolescents and adults. Using recen…
Background Alcohol and cannabis are commonly used substances for young adults, and person-level co-use (i.e., concurrent or simultaneous use of both) is associated with increased likelihood of experiencing positive and negative alcohol-related consequences. However, findings regarding within-person effects (i.e.,day-level) co-use on consequences are mixed, possibly due to inconsistency in including alcohol quantit…
Introduction The co-use of substances confers risks above single-product use and has significant public health implications. This study investigated trends in past 30-day co-use of nicotine/tobacco products with alcohol and cannabis in the US using Population Assessment of Tobacco and Health Study data from Waves 4-6 (December 2016-November 2021). Methods All wave 4-6 PATH participants age 15+ were included in ana…
Open article record in new tab ↗Gut-brain signaling influences alcohol consumption and addiction behaviors. We found that selectively deleting cannabinoid receptor 1 (CB1R) from advillin+ peripheral sensory neurons eliminates the inhibitory effect of the peripheral CB1R antagonist JD5037 on voluntary ethanol intake (VEI). Similar results were seen in mice with CB1R deletion in Phox2b+ nodose ganglia (NGA), but not in Wnt+ dorsal root ganglia. Th…
Background Alcohol-induced blackouts (AIBs) are a serious consequence of alcohol use that are strongly associated with experiencing excess alcohol-related harms. AIBs are common and recurrent among young adults who drink. The risk factors for AIBs include dynamics of alcohol use (quantity, speed, duration), alcohol-related behaviors (eg, playing drinking games, not using protective behavioral strategies), and fact…
Objective: The use of recreational drugs such as alcohol and tetrahydrocannabinol(THC) is increasing worldwide. While tobacco and certain illicit substances are well-established risk factors for aneurysmal subarachnoid hemorrhage (aSAH), the role of alcohol and THC remains less well defined. Understanding their potential impact on aneurysm rupture and clinical severity could have significant implications for preve…
Objective Alcohol and cannabis co-use is the most common form of polysubstance use in the U.S. Some evidence suggests that there is an association between cannabis use and reduced alcohol consumption, however data on this topic are mixed. Further research is needed to elucidate the individual factors that determine whether cannabis substitutes for alcohol. Method This study is an exploratory analysis of data from…
Open article record in new tab ↗Background Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations have diverse cultural, immigration, and sociodemographic characteristics. Aggregated data could mask substantial differences in substance use between cultural subgroups in this population. Yet, studies examining substance use among the AANHPI population are limited. Objective This study aimed to describe cigarette, cannabis, and…
Background Sleep-promotion is one of the most common reasons people use cannabis. Previous studies, primarily among young adults, suggest that cannabis use has negligible day-level effects on sleep but may attenuate alcohol's negative effects when both substances are used. Studies among middle-aged/older adults are needed to determine the generalizability of these day-level associations. Methods This preregistered…
Open article record in new tab ↗Purpose To identify associations of past-year witnessing violence with expectancies (anticipated effects) for alcohol and cannabis use in Black, Latinx, and White youth, including possible variations by level of neighborhood advantage and/or race/ethnicity. Methods Data were drawn from Follow-up 3 of the Adolescent Brain Cognitive Development Study (n=7,332; weighted distributions: 45.53% girl, 52.33% boy, 2.14% o…
Combined use of alcohol and illicit drugs is a serious health and social problem. In this study, it was examined, whether a relationship between alcohol and drug abuse can be ascertained by comparison of alcohol marker and drug concentrations in hair. In the frame of a social support system for families with parental abuse of illicit drugs, hair samples were analyzed between 2011 and 2022 for methadone, heroin (6-…