Dear Editor,

Medical Marijuana (Cannabis sativa L.) is presently widely used due to legalization in many countries.[1] An important consideration is the effect of Marijuana on other medical disorders. Here, the authors focus special interest on COVID-19, the new emerging coronavirus infection. A basic question is whether there is any interrelationship between the pathological pathway of coronavirus infection and the pharmacological pathway of Marijuana.

The authors hereby performed bioinformatics pathway analysis using primary data from mining. The reference database is PubMed. Briefly, the standard pathway interrelationship analysis is used for referencing paper.[2] First, the common pathway was searched then creation of an interrelationship was done. Based on the present study, there is an important identified common mode between the pathological pathway of coronavirus infection and the pharmacological pathway of Marijuana, the Th1 and Th17 immune response was found.[34] The interrelation map is shown in Figure 1. This result shows that the use of Marijuana can impair resistance to coronavirus infection and might be a risk for severe disease. However, an important limitation of the present informatics study is that the model is not based on COVID-19 but a highly similar coronavirus infection, Middle East respiratory distress syndrome.[3] Further studies on Marijuana (Cannabis sativa L.) and COVID-19 in vivo model are required to confirm the present in silico study.