Dear Editor,

Re-emergence of monkeypox is a significant global public health problem. In general, monkeypox is a kind of viral infection that is in the same group as smallpox infection. When there is a cessation of routine smallpox vaccination, there is a gradual decrease in immunity and it results in the present emergence of monkeypox. Now, the disease has become a global problem and has been reported in several countries outside Africa, as the origin of the infection. It is possible to miss diagnosing the illness when it manifests as a skin lesion and fever.[1] Additionally conceivable are uncommon clinical issues including gastrointestinal issues.[1] An interesting topic for many ongoing studies, is the treatment of monkeypox. It would be interesting to conduct a study on the function of conventional herbal management. The authors want to talk about how licensed medical Marijuana (Cannabis sativa L.) can be used here to treat monkeypox. The potential role in symptomatic and supportive care, particularly for pain management, is suggested.[2] The role of cannabidiol in virus suppression is also mentioned.[2] However, there has been no concrete research on Marijuana potential to treat monkeypox. As Vallee[3] points out, cannabis and alcohol consumption may have two negative effects on the monkeypox virus (MPXV) outbreak: increasing the number of sexual partners, which is primarily responsible for the increase in the number of new MPXV-infected cases, and impairing the immune response to a viral infection. It should be noted, however, that medical Marijuana with a well-controlled therapeutic approach can be useful and is not linked to addiction.[4] Medical Marijuana potential role in the treatment of monkeypox should be investigated further. According to the literature, cannabinoids may have clinical effects through the inflammatory response as well as neuroprotective effects.[5] The fundamental pharmacological activities that are suggested as being advantageous in the therapeutic treatment of cannabis on viral infections, particularly HIV-1, are listed.[4] Additionally, whether or not they operate through a specific receptor, cannabinoids have the capacity to modulate mitochondria, which has the potential to have an impact on a variety of cell types.[4]