Cannabidiol Suppresses EMT in Pancreatic Cancer via Inhibition of MALAT1 lncRNA and PI3K/Akt/mTOR Signaling Pathway

Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive metastasis and poor response to chemotherapy, largely driven by epithelial–mesenchymal transition (EMT) and chemokine signaling. Cannabidiol (CBD), a non‐psychoactive phytocannabinoid, has shown anticancer potential, yet its mechanisms in EMT regulation remain underexplored in PDAC. In this study, we demonstrate that CBD significantly suppresses the expression of CXCR4/CXCR7 and matrix metalloproteinases (MMP‐2/9), leading to reduced migration and invasion of MIA PaCa‐2, PANC‐1, and AsPC‐1 cells. Moreover, CBD reversed CXCL12‐induced EMT by downregulating