Therapeutic Cannabis and Endocannabinoid Signaling System Modulator Use in Otolaryngology Patients

Abstract Objectives: 1) review benefits and risks of cannabis use, with emphasis on otolaryngic disease processes; 2) define and review the endocannabinoid signaling system (ESS); and 3) review state and federal regulations for the use and research of cannabis and ESS modulators. Methods: This manuscript is a review of the current literature relevant to the stated objectives. Results: Cannabis (marijuana) use is increasing. It is the most widely used illicit substance in the world. There is increasing interest in its