Clinical value of SPP1 overexpression in patients with papillary thyroid carcinoma

Abstract Background: Secreted phosphoprotein 1 (SPP1) is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family. SPP1 is known to be involved in various cancer-related signaling pathways. Nevertheless, limited research has been conducted on the association between SPP1 and papillary thyroid carcinoma (THCA). This study aimed to investigate the expression of SPP1 in papillary THCA and its relationship with clinical relevance and immune cell infiltration. Methods: The expression and prognosis of SPP1 in pan-cancer were analyzed using The