Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3
Abstract The centromere is a unique chromosomal locus that ensures accurate segregation of chromosomes during cell division by directing the assembly of a multiprotein complex, the kinetochoreref. 1. The centromere is marked by a conserved variant of conventional histone H3 termed CenH3 or CENP-Aref. 2. A conserved motif of CenH3, the CATD, defined by loop 1 and helix 2 of the histone fold, is necessary and sufficient for specifying centromere functions of CenH3ref. 3, ref. 4. The structural basis of
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