The roles of FLOT1 in human diseases (Review)

Abstract FLOT1, a scaffold protein of lipid rafts, is involved in several biological processes, including lipid raft protein-dependent or clathrin-independent endocytosis, and the formation of hippocampal synapses, amongst others. Increasing evidence has shown that FLOT1 can function as both a cancer promoter and cancer suppressor dependent on the type of cancer. FLOT1 can affect the occurrence and development of several types of cancer by affecting epithelial-mesenchymal transition, proliferation of cancer cells, and relevant signaling pathways, and is regulated by long