Theoretical Analysis of d‐Serine and d‐Asparagine as Biomarkers for Glomerular Filtration Rate

Abstract Chronic kidney disease (CKD) is a major global health issue, requiring accurate and noninvasive renal function assessment. Glomerular filtration rate (GFR) is the standard measure, but current methods, including inulin clearance and creatinine‐based estimation, have limitations in accuracy, invasiveness, and practicality. We investigated d‐serine and d‐asparagine as novel endogenous biomarkers for GFR evaluation. Their clearance strongly correlates with inulin clearance, demonstrating high reliability and reduced muscle mass dependency compared to creatinine‐based methods. Our findings suggest that d‐amino acids offer