The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing

Abstract In this review, Rambout and Maquat discuss known roles of the nuclear cap-binding complex (CBC) during the transcription of genes that encode proteins, stitching together past studies from diverse groups to describe the continuum of CBC-mediated checks and balances in eukaryotic cells. Article type: Review Article Keywords: CBP80, CBP20, CBC, transcription preinitiation complex, transcription initiation, promoter-proximal pausing, transcription elongation, RNA 3′ end formation, transcription termination, pre-mRNA splicing, alternative splicing Authors: Xavier Rambout, Lynne E. Maquat Affiliations: Department of Biochemistry