Predictive Value of Mean Platelet Volume and Other CBC Indices for Thrombocytopenia in Pediatric Dengue Fever: A Prospective Observational Study

Abstract Introduction: Dengue fever is a major pediatric health challenge, with thrombocytopenia as a key severity marker. Objectives: To assess the predictive value of mean platelet volume, MPV-to-platelet ratio, and other complete blood count (CBC) indices for severe thrombocytopenia in pediatric dengue. Methods: This prospective observational study enrolled 127 children (1 month–15 years) with confirmed dengue at Hue Central Hospital, Vietnam (January 2023-July 2025). CBC parameters were measured on illness days 3 and 6. Severe thrombocytopenia was defined as platelet