Corticobasal degeneration preceded by cognitive impairment and apathy: An autopsy case report

Abstract Background: Corticobasal degeneration (CBD) presents with a range of clinical phenotypes, making diagnosis challenging. We report the clinical course of a patient with autopsy‐confirmed CBD who initially presented with cognitive impairment and apathy, without motor symptoms. Case Presentation: A 51‐year‐old man presented to our hospital with decreased motivation, amnesia, and executive dysfunction. Memory disturbance and frontal lobe dysfunction were evident on examination. No motor symptoms such as Parkinsonism, apraxia, or oculomotor abnormalities were apparent. Magnetic resonance imaging and brain