The SUMO specific peptidase SENP3 promotes papillary thyroid cancer progression by deSUMOylation of SETDB1 and regulating GLI2 transcription

Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10238-026-02151-1. Article type: Research Article Keywords: Papillary thyroid cancer, SENP3, SETDB1, GLI2, PI3K/AKT pathway Authors: Zhe Wang, Ze Yang, Yong Chen, Xiaojing Zhao, Dengfeng Gao, Nancy Wang, Albert Williams Affiliations: https://ror.org/017zhmm22grid.43169.390000 0001 0599 1243Department of General Medical, The Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, 710004 China; https://ror.org/02y9xvd02grid.415680.e0000 0000 9549 5392Department of Clinical Laboratory, The Affiliated Central Hospital of Shenyang Medical College, Shenyang, 110000 China; Department