Cumulative Effects of Cannabis Oils on Body Temperature, Electrocardiography, Heart Rate Variability, Blood Pressure, and Respiratory Function in Telemetered Dogs

Abstract Background: Cannabis oils are progressively being investigated as potential treatments for various health conditions in dogs. However, their safety profiles in this species remain poorly understood. Objectives: This study evaluated the effects of incremental doses of cannabis oils containing tetrahydrocannabinol (THC), cannabidiol (CBD), and their combination (THC + CBD) on cardiovascular and respiratory parameters in dogs. Materials and Methods: Six male Beagles participated in a 3 × 3 crossover study. Acute cumulative doses (1, 2, 4, 8, and 16