CBC ratios for early sepsis risk stratification in newborns: EOS/LOS versus non-septic controls

Abstract Background: Despite advances in neonatal intensive care units (NICUs), neonatal sepsis remains a leading cause of morbidity and mortality worldwide. Early and accurate diagnosis is challenging because clinical signs are often nonspecific and no single biomarker has shown perfect sensitivity and specificity. Recently, complete blood count–based parameters such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have gained attention as simple and low-cost markers of systemic inflammatory response. This study was designed to assess the diagnostic utility of