Analysis of seven selected cannabinoids in human plasma highlighting matrix and solution stability assessments

Abstract Cannabis consumption has and continues to increase dramatically, as does its legalization for recreational and/or medicinal use at the state, but not at the federal level. The increased consumption and legalization have spurred significant cannabis focused research, with particular interest in defining the pharmacokinetic characteristics of this complex natural product. Supporting this research requires a bioanalytical method that accurately and simultaneously quantifies the primary cannabinoids and their metabolites. The objective of this method validation was to meet pre-specified sensitivity