Utility of CBC-derived ratios in the diagnosis and prediction of active tuberculosis in people with rheumatic diseases

Abstract Objective: Active tuberculosis (ATB) largely relied on clinical diagnosis because of the limited sensitivity of microbiologic testing. We assessed whether complete blood cell count (CBC)-derived ratios could assist in ATB diagnosis and risk assessment. Methods: This study enrolled 305 people with ATB and 171 healthy controls (HC) to evaluate the diagnostic efficiency of CBC-derived ratios for ATB by receiver operating characteristic curves and validated in a multi-center rheumatic disease (RD) cohort, in which a nested case-control study was designed