Cell-free DNA as a prognostic and predictive biomarker in resectable distal common bile duct cancer

Abstract Background: Cell-free DNA (cfDNA) as an oncological biomarker has drawn much attention in recent years, but very limited effort has been made to investigate the prognostic values of cfDNA in distal common bile duct (CBD) cancer. Methods: Plasma cfDNA was measured in 67 patients with resectable distal CBD cancer. Survival outcomes and the correlation of cfDNA with other conventional prognostic factors were determined. Results: cfDNA levels were significantly higher in female patients, and those with poor tumor differentiation, abnormal