Cannabinoid Receptor Modulation in Focal Ischemic Stroke: A Systematic Review and Meta-Analysis of Infarct Volume and Behavioral Deficits in Animal Models

Abstract Objective: This systematic review and meta-analysis aimed to evaluate the impact of cannabinoid (CB) receptor modulation on infarct volume and behavioral deficits in animal models of focal ischemic stroke, with a primary focus on infarct outcomes. Method: A comprehensive literature search was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, yielding 29 eligible studies for inclusion. Results: The analysis revealed significant reductions in infarct volume with CB agonists, particularly CB1 and CB2 agonists, indicating their