Clinical significance of ANXA9 expression in colorectal cancer and its impact on immune evasion and drug resistance

Abstract Background: Colorectal cancer (CRC) is a major global health challenge, creating an urgent need to find new biomarkers that improve early detection and treatment success. While studies suggest that ANXA9 contributes to cancer development, its expression in CRC and its links to prognosis, immune evasion, and resistance are poorly understood. Methods: This study conducted bioinformatics analysis of gene expression data from the TCGA and GEO to evaluate the prognostic and diagnostic potential of ANXA9. Kaplan-Meier survival analysis and ROC