Comprehensive pan-cancer analysis of NLRs family as prognostic and immunity markers based on multi-omics data

Abstract Background: Members of the NOD-like receptors(NLRs)gene family members involved in inflammasome formation have been implicated in cancer initiation, development, progression, angiogenesis, and invasion. This study comprehensively investigated the role of NLRs in cancer through multi-omics analysis, which is of great necessity for a deeper understanding of the pathogenesis of cancer, improvement of cancer prognosis assessment, promotion of drug development, and advancement of precision medicine. Methods: A multi-omics analysis was performed on data from over 10,000 individuals, integrating genomics, epigenomics,