Identification of GBN5 as a molecular biomarker of pan-cancer species by integrated multi-omics analysis

Abstract Introduction: We conducted a panoramic analysis of GBN5 expression and prognosis in 33 cancers, aiming to deepen the systematic understanding of GBN5 in cancer. Materials and methods: We employed a multi-omics approach, including transcriptomic, genomic, proteomic, single-cell cytomic, spatial transcriptomic, and genomic data, to explore the prognostic value and potential oncogenic mechanisms of GBN5 across pan-cancers from multiple perspectives. Results: We found that GBN5 was differentially expressed in multiple tumors and showed early diagnostic value. Mutations, somatic copy number