Interaction of germline variants in a family with a history of early‐onset clear cell renal cell carcinoma

Abstract Background: Identification of genetic factors causing predisposition to renal cell carcinoma has helped improve screening, early detection, and patient survival. Methods: We report the characterization of a proband with renal and thyroid cancers and a family history of renal and other cancers by whole‐exome sequencing (WES), coupled with WES analysis of germline DNA from additional affected and unaffected family members. Results: This work identified multiple predicted protein‐damaging variants relevant to the pattern of inherited cancer risk. Among these, the