Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier

Abstract The first PTC patient classifier defined by tumor macrophage differentiation. Integrated sequencing data identifies key gene sets. Macrophage states in PTC link to immune/metabolic shifts. Poor prognosis PTC patient group shows M2 macrophage traits. Article type: Research Article Keywords: Multi-omics, Single-cell RNA sequencing, Papillary thyroid carcinoma, Tumor immune microenvironment, Macrophage differentiation Authors: Hanlin Sun, Zhengyan Chang, Hongqiang Li, Yifeng Tang, Yihao Liu, Lixue Qiao, Guicheng Feng, Runzhi Huang, Dongyan Han, De-tao Yin Affiliations: Department of Thyroid Surgery, the First