Adrenomedullin2 stimulates progression of thyroid cancer in mice and humans under nutrient excess conditions

Abstract Thyroid cancer is associated with genetic alterations, e.g. BRAFV600E, which may cause carcinomatous changes in hormone‐secreting epithelial cells. Epidemiological studies have shown that overnutrition is related to the development and progression of cancer. In this study, we attempted to identify the cell nonautonomous factor responsible for the progression of BRAFV600E thyroid cancer under overnutrition conditions. We developed a mouse model for inducible thyrocyte‐specific activation of BRAFV600E, which showed features similar to those of human papillary thyroid cancer. LSL‐Braf V600E;TgCreERT2