Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer

Abstract Background: ADAM12, a member of the disintegrin and metalloproteinase family, has been involved in multiple cancers, yet its precise role in pan-cancer progression still remains elusive. Methods: In our current study, we conducted a comprehensive analysis of ADAM12 expression, diagnosis, prognosis, genomic variations, DNA methylation, functional enrichment, immune infiltration as well as immunotherapy in pan-cancer utilizing public datasets. Additionally, a series of biological functional experiments of ADAM12 were performed in gastric cancer cells including cell counting kit-8 (CCK-8), colony