In silico pan-cancer analysis of VRAC subunits and their prognostic roles in human cancers

Abstract The study focuses on the VRAC channel and its significant roles in cancer development. It addresses a research gap by conducting a pan-cancer analysis with multi-omics bioinformatics tools, integrating data from the Human Protein Atlas (HPA) and Genotype-Tissue Expression (GTEx) datasets to examine mRNA expression patterns of its Leucine Rich Repeat Containing 8 (LRRC8) subunits in various tissues and cancers. The study links variations in LRRC8s expression with patient outcomes and includes analyses of DNA and RNA methylation. The