Systematic Characterization of DNA Methyltransferases Family in Tumor Progression and Antitumor Immunity
Abstract Objective: DNA methylation is an essential epigenetic marker governed by DNA methyltransferases (DNMTs), which can influence cancer onset and progression. However, few studies have provided an integrated analysis of the relevance of DNMT family genes to cell stemness, the tumor microenvironment (TME), and immunotherapy biomarkers across diverse cancers. Methods: This study investigated the impact of five DNMTs on transcriptional profiles, prognosis, and their association with Ki67 expression, epithelial–mesenchymal transition signatures, stemness scores, the TME, and immunological markers across 31
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