Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6

Abstract BACKGROUND: Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), a member of the ENTPD family, has been implicated in certain cancers, yet a comprehensive analysis across multiple cancer types remains lacking. AIM: To systematically evaluate ENTPD6’s expression, prognostic significance, and functions across multiple cancer types. METHODS: In this study, we performed a pan-cancer analysis to investigate the correlation between ENTPD6 expression and various factors, including prognosis, genetic alterations, epigenetic modification, immune infiltration, immunotherapy responses, functional enrichment, and drug sensitivity. A tissue microarray