Knockdown of HGH1 in breast cancer cell lines can inhibit the viability, invasion and migration of tumor cells
Abstract Background: Research on the function of HGH1 in breast cancer remains lacking. Methods: TCGAand GEO (GSE45827) datasets investigated discrepancies in HGH1 expression in BC. An aggregate of 106 clinical samples were gathered through immunohistochemistry, KM curves were drawn for prognostic analysis, and the function of HGH1 of BC was predicted. Finally, the effects of HGH1 knockdown on MDA-MB-231 and MCF-7 BC cells were verified via CCK8, invasion, wound healing and colony formation assays. Results: HGH1 is highly expressed in
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