Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the pan cancer landscape

Abstract Background: MRPL3, a member of the mitochondrial ribosomal family, is involved in the translation of mitochondria-related proteins. However, its role in tumors remains unclear. Objective: To elucidate the oncogenic role and prognostic significance of MRPL3 in cancer. Methods: We conducted a pan-cancer analysis of MRPL3 using various databases, bioinformatics and statistical tools, as well as tissue microarray analysis. Results: MRPL3 was generally upregulated in tumors compared to normal tissues. Its expression showed a negative correlation with immunogenic markers, immune