A pan-cancer landscape of centromere proteins in tumorigenesis and anticancer drug sensitivity

Abstract CENPs activated the cell cycle signaling pathway and inhibited the RAS/MAPK, hormone ER and hormone AR pathways. CENP family genes was significantly correlated with a poor prognosis for cancer patients. Highly heterogeneous genetic variation in CENP family genes across cancers. CENP family gene expression was correlated with chemosensitivity and immunotherapy responses. Article type: Research Article Keywords: Pan-cancer, Centromere proteins, Tumor microenvironment, Immune infiltration, Drug sensitivity Authors: Yuan-Xiang Shi, Peng-Hui Dai, Yu-Fei Jiang, Yan-Qing Wang, Wen Liu Affiliations: Institute of