A Pan-Cancer Analysis of Natriuretic Peptide Receptor 3 (NPR3) with Clinical Cohort and in vitro Validation

Abstract Background: Natriuretic peptide receptor 3 (NPR3) regulates natriuretic peptides and plays a key role in angiogenesis, immune regulation, and progression of certain cancers. However, the clinical significance of NPR3 at pan-cancer level remains poorly understood. This study aimed to comprehensively analyze NPR3’s role across multiple cancers, focusing on its potential as a prognostic biomarker, particularly in kidney cancer. Methods: A comprehensive pan-cancer study of NPR3 was conducted using 20 different databases and datasets. The study included differential expression analysis,