Bystin is a Prognosis and Immune Biomarker: From Pan-Cancer Analysis to Validation in Breast Cancer

Abstract Introduction: The Bystin gene (BYSL) contributes to cancer development and is a probable therapeutic target in cancer therapy. However, no systematic studies have been conducted on BYSL value in pan-cancer diagnosis, prognosis, and immunology. Methods: We performed a pan-cancer analysis of BYSL using TCGA, GEO, and other databases to assess its expression, clinical significance, genetic variants, methylation, and immune correlation. Enrichment analysis was applied to predict BYSL-related pathways. We analyzed BYSL protein levels in corresponding breast cancer (BRCA) tissue