Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer

Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-89308-2. Article type: Research Article Keywords: PVRIG, Prognosis, Immune checkpoint, Cancer, Immunotherapy, Cancer, Computational biology and bioinformatics, Cancer Authors: Peng Ma, Ruichen Zhang, Weili Sun Affiliations: https://ror.org/05bhmhz54grid.410654.20000 0000 8880 6009Department of Gastroenterology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei Province People’s Republic of China; https://ror.org/02d3fj342grid.411410.10000 0000 8822 034XDepartment of Electronic Information Engineering, Hubei University of Technology, Wuhan, Hubei Province People’s Republic of China; https://ror.org/01pxwe438grid.14709.3b0000 0004 1936 8649Division of