Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer
Abstract Background: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells. Methods: Three PTC cell lines (MDA‐T32, MDA‐T68, and MDA‐T85) were analyzed for expression using RT‐qPCR and immunofluorescence. Live cell imaging measured calcium responses to six bitter agonists. Viability and apoptosis effects were assessed using crystal violet and caspase 3/7
This article is available to registered members
Create a free account to access our full library of peer-reviewed research on medical cannabis.
Join — it's freeAlready a member? Log in